New research indicates that people who come off blockbuster GLP-1 drugs like Mounjaro or Wegovy tend to recover shed pounds far faster than those who end conventional diet and exercise programs.
Published data in a prominent medical journal demonstrates that while obese people can lose a large proportion of their body weight while on the medication, the mass returns at an estimated rate of 0.8 kg per month after stopping.
"People using such drugs need to be informed of the danger of rapid weight regain when the medication is stopped," stated expert Dr. Susan Jebb.
This pace of regain suggests a reversion to original mass within about a year and a half.
Analyzing Treatments
The research, which reviewed dozens of studies involving thousands of participants, compared the outcomes of these new drugs with other pills.
Scientists point out that individuals who lose weight through dieting usually experience a more gradual weight regain—approximately 100 grams monthly—after stopping.
Explaining the Quick Rebound
Experts suggest the mode of action of the injections accounts for the accelerated weight return.
These medications imitate a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the system to generate a reduced amount of its endogenous GLP-1, and may also diminish responsiveness to its actions," explained Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication leads to appetite is no longer kept in check, making excessive eating far more likely."
A Lifelong Issue?
The NHS recommend the jabs for individuals with obesity-related health risks, accompanied by recommended lifestyle changes.
Professionals contend that, given the likelihood of relapse, the therapy is often ongoing.
This perspective is supported by drug manufacturers, who state that the findings "underscore the long-term nature of excess weight," akin to managing diseases like high blood pressure.
Patient Experiences
Users who have come off the medication report a intense return of hunger.
"It was like a trigger flipping and you become extremely hungry," said an individual.
This difficulty is worsened if individuals have not adopted lasting lifestyle or habit changes during treatment.
Widespread Adoption
Survey data indicate that millions of adults in the UK have tried weight-loss jabs in the last 12 months, with demand being substantial.
- Adoption is more common among women compared to men.
- The middle-aged demographic shows the greatest level of interest.
- Many obtain the medications through private prescriptions rather than the NHS.
In conclusion, experts caution that while GLP-1 drugs are powerful agents for weight loss, they are not a permanent cure and maintained weight loss relies on integrated behavioural support.
